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rs2427837

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) lowest IgE levels
(A;G) lower IgE levels
(G;G) 0 normal but highest IgE levels
ReferenceGRCh38 38.1/141
Chromosome1
Position159288755
GeneFCER1A
is asnp
is mentioned by
dbSNPrs2427837
dbSNP (old)rs2427837
ClinGenrs2427837
ebirs2427837
HLIrs2427837
Exacrs2427837
Varsomers2427837
Maprs2427837
PheGenIrs2427837
Biobankrs2427837
1000 genomesrs2427837
hgdprs2427837
ensemblrs2427837
gopubmedrs2427837
geneviewrs2427837
scholarrs2427837
googlers2427837
pharmgkbrs2427837
gwascentralrs2427837
openSNPrs2427837
23andMers2427837
23andMe allrs2427837
SNP Nexus

SNPshotrs2427837
SNPdbers2427837
MSV3drs2427837
GWAS Ctlgrs2427837
GMAF0.1538
Max Magnitude0
rs2427837 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases.

An examination of over 11,000 Germans led to the conclusion that rs2427837 (and one other FCER1A SNP, the tightly linked rs2251746) were strongly associated with high levels of serum IgE. The more common (G) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous rs2251746(G;G) individuals may be at higher risk for atopic eczema and asthma than carriers of one or two (A) alleles. [PMID 18846228OA-icon.png]

? (A;A) (A;G) (G;G)
[PMID 22222815] Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population


[PMID 24354852] A role of FCER1A and FCER2 polymorphisms in IgE regulation


[PMID 23725541] Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.


[PMID 27746735OA-icon.png] FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.