Variation at this SNP, rs2298383, appears to influence how an individual responds to moderate levels (150mg) of caffeine.[PMID 18305461]
[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality
[PMID 22336631] Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.
[PMID 23535492] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus
[PMID 26589317] The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder
[PMID 30511252] Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study.
[PMID 31817803] The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.
[PMID 32182774] The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.