|(A;A)||1.5||1.4x increased risk of SLE|
|(A;G)||1.5||1.4x increased risk of SLE|
|(G;G)||1||Normal risk of SLE|
[PMID 19228650] A meta-analysis comprising 5 case-control studies, totaling 6,582 rheumatoid arthritis cases and 5,375 controls, concluded that several IRF5 gene SNPs were indeed (still) significantly associated with the disease. The rs2280714(A) allele was associated with a slight protective effect (odds ratio 0.9, CI: 0.87-0.99, p = 0.029).PMID 19816589] Lack of association of two polymorphisms of IRF5 with Behcet's disease
[PMID 19854706] Association of IRF5 polymorphisms with activation of the interferon alpha pathway
[PMID 21239750] Association of IRF5 Polymorphisms with Susceptibility to Macrophage Activation Syndrome in Patients with Juvenile Idiopathic Arthritis
[PMID 15657875] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
[PMID 17133578] Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis.
[PMID 17189288] Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
[PMID 17412832] Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
[PMID 18050197] Association of an IRF5 gene functional polymorphism with Sjogren's syndrome.
[PMID 18200047] IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population.
[PMID 18285424] Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.
[PMID 18668568] Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.
[PMID 18846218] Evolutionary signatures of common human cis-regulatory haplotypes.
[PMID 19109131] Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
[PMID 20479942] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
[PMID 21834935] A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.
[PMID 21898142] Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children.
[PMID 23073787] Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis
[PMID 23288367] Interferon regulatory factor 5 polymorphisms in sarcoidosis.
[PMID 25036352] Association between IRF5 polymorphisms and autoimmune diseases: a meta-analysis