rs2235749
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in clinvar |
| Make rs2235749(A;A) |
| Make rs2235749(A;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 20 |
| Position | 1979293 |
| Gene | LOC727993, PDYN |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2235749 |
| dbSNP (classic) | rs2235749 |
| ClinGen | rs2235749 |
| ebi | rs2235749 |
| HLI | rs2235749 |
| Exac | rs2235749 |
| Gnomad | rs2235749 |
| Varsome | rs2235749 |
| LitVar | rs2235749 |
| Map | rs2235749 |
| PheGenI | rs2235749 |
| Biobank | rs2235749 |
| 1000 genomes | rs2235749 |
| hgdp | rs2235749 |
| ensembl | rs2235749 |
| geneview | rs2235749 |
| scholar | rs2235749 |
| rs2235749 | |
| pharmgkb | rs2235749 |
| gwascentral | rs2235749 |
| openSNP | rs2235749 |
| 23andMe | rs2235749 |
| SNPshot | rs2235749 |
| SNPdbe | rs2235749 |
| MSV3d | rs2235749 |
| GWAS Ctlg | rs2235749 |
| GMAF | 0.4784 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18923396
] In Caucasians, we found point-wise significant associations of 3' UTR SNPs (rs910080, rs910079, and rs2235749) with cocaine dependence and cocaine/alcohol codependence.
[PMID 21382455] Association between heroin dependence and prodynorphin gene polymorphisms
[PMID 21521424] Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics
[PMID 27074815] A Functional 3'UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits
| ClinVar | |
|---|---|
| Risk | rs2235749(A;A) |
| Alt | rs2235749(A;A) |
| Reference | Rs2235749(G;G) |
| Significance | Non-pathogenic |
| Disease | Spinocerebellar Ataxia |
| Variation | info |
| Gene | PDYN LOC727993 |
| CLNDBN | Spinocerebellar Ataxia, Dominant |
| Reversed | 0 |
| HGVS | NC_000020.10:g.1959939G>A |
| CLNSRC | |
| CLNACC | RCV000401555.1, |
