||Normal risk of developing restless legs syndrome
||1.3x increased risk of developing restless legs syndrome
||>1.3x increased risk of developing restless legs syndrome
rs1975197, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs1975197(T) risk allele is 1.31 (CI: 1.20-1.44, adjusted p = 5 x10e-9). [PMID 18660810]
Note that a nearby SNP, rs4626664, was also shown to independently confer risk for restless legs syndrome in this same study.
|Desc||RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 3|
[PMID 21264940] Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome
||Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
Restless Legs Syndrome: Preliminary Research
[PMID 25142570] Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD