|(A;A)||2||2x increased risk for thyroid cancer|
|(A;G)||1.5||1.5x increased risk for thyroid cancer|
Based on ~1,000 thyroid cancer patients (and an equal number of controls), a per allele odds ratio of 1.49 (CI: 1.30-1.70, p=5.9x10e-9) was found for the rs1867277(A) allele. This allele is thought to be a causal variant.[PMID 19730683]
[PMID 22282540] Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
[PMID 22493691] Novel associations for hypothyroidism include known autoimmune risk loci.
[PMID 22736773] Association of FOXE1 polyalanine repeat region with papillary thyroid cancer.
[PMID 22882326] FOXE1 polymorphisms are associated with familial and sporadic nonmedullary thyroid cancer susceptibility.
[PMID 23327367] Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry.
[PMID 25849217] Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population
[PMID 25879635] Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population
[PMID 27824288] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma.
[PMID 28660995] Age at diagnosis and gender modify the risk of 9q22 and 14q13 polymorphisms for papillary thyroid carcinoma.