|(G;G)||2.1||2x increased risk for macular degeneration|
|?||(A;A) (A;G) (G;G)||28|
linked to blindness in age related macular degeneration
rs3753394, rs800292, rs1061147, rs1061170, rs380390, and rs1329428
Significant associations were detected for AMD with rs3753394 rs800292 rs1329428
A haplotype of rs3753394 rs800292 rs1061170 rs1329428 (TGTC) was found to confer a significantly increased likelihood of exudative AMD
CFH variations appear to contribute to ARMD in Caucasians, but not in Japanese [PMID 16710702]
|Title||Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration|
|Odds Ratio||2.78 [NR]|
[PMID 15761122] Complement factor H polymorphism in age-related macular degeneration.
[PMID 16936733] CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.
[PMID 17167412] Association of complement factor H polymorphisms with exudative age-related macular degeneration.
[PMID 18048322] A forest-based approach to identifying gene and gene gene interactions.
[PMID 18421087] Multiple gene polymorphisms in the complement factor h gene are associated with exudative age-related macular degeneration in chinese.
[PMID 19026761] Molecular pathology of age-related macular degeneration.
[PMID 19187823] Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy.
[PMID 19208169] A random forest approach to the detection of epistatic interactions in case-control studies.
[PMID 19412524] Epistatic module detection for case-control studies: a Bayesian model with a Gibbs sampling strategy.
[PMID 19958499] A particle swarm based hybrid system for imbalanced medical data sampling.
[PMID 20122224] A multi-filter enhanced genetic ensemble system for gene selection and sample classification of microarray data.
[PMID 20161815] SERPING1 polymorphisms in polypoidal choroidal vasculopathy.
[PMID 20181037] Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration.
[PMID 21111031] Correlation of complement factor H gene polymorphisms with exudative age-related macular degeneration in a Chinese cohort.
[PMID 21342556] The choice of null distributions for detecting gene-gene interactions in genome-wide association studies.
[PMID 24365176] Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy
[PMID 26296146] PREVALENCE OF THE COMPLEMENT FACTOR H AND GSTM1 GENES POLYMORPHISMS IN PATIENTS WITH CENTRAL SEROUS CHORIORETINOPATHY