|| increased risk for psoriasis
|| possibly increased risk of psoriasis
|?|| (C;C) (C;G) (G;G) ||28|
is a SNP in the HLA region of chromosome 6.
A large study (>6,000 Chinese psoriasis patients and an equal number of controls) found a highly significant association between the minor rs1265181(G) allele and risk for psoriasis.[PMID 19169255] A proxy for this allele is rs1265159(A).
23andMe blog psoriasis
|| [PMID 19169255]
|| Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
| Risk Allele
| Odds Ratio
|| 22.62 None
[PMID 21208785] Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population
[PMID 19680446] Multiple Loci within the major histocompatibility complex confer risk of psoriasis.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20606885] Genetics of psoriasis and psoriatic arthritis.
[PMID 27073425] Candidate gene polymorphisms and risk of psoriasis: A pilot study