rs11650354

plus

Geno	Mag	Summary
(C;C)	0	common/normal
(C;T)	1.1	possible risk for allergic asthma
(T;T)	2	8x risk for allergic asthma

Reference

GRCh38 38.1/141

Chromosome

17

Position

47744726

Gene

TBX21

is a	snp
is	mentioned by
dbSNP	rs11650354
dbSNP (classic)	rs11650354
ClinGen	rs11650354
ebi	rs11650354
HLI	rs11650354
Exac	rs11650354
Gnomad	rs11650354
Varsome	rs11650354
LitVar	rs11650354
Map	rs11650354
PheGenI	rs11650354
Biobank	rs11650354
1000 genomes	rs11650354
hgdp	rs11650354
ensembl	rs11650354
geneview	rs11650354
scholar	rs11650354
google	rs11650354
pharmgkb	rs11650354
gwascentral	rs11650354
openSNP	rs11650354
23andMe	rs11650354
SNPshot	rs11650354
SNPdbe	rs11650354
MSV3d	rs11650354
GWAS Ctlg	rs11650354

GMAF

0.1244

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

A large study of Caucasian children has identified this SNP in the TBX21 gene (and one other, rs16947078) as defining a haplotype associated with increased risk for allergic asthma. [PMID 17949803]

The odds ratio associated with rs11650354(T;T) homozygotes compared to rs11650354(C;C) homozygotes for allergic asthma is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk. [PMID 17949803]

[PMID 19950257 ] Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines