rs110419

plus

Geno	Mag	Summary
(A;A)	2	1.7x increased risk for neuroblastoma
(A;G)	1.3	1.3x increased risk for neuroblastoma
(G;G)	0

Reference

GRCh38 38.1/141

Chromosome

11

Position

8231306

Gene	LMO1, LOC105376536

is a	snp
is	mentioned by
dbSNP	rs110419
dbSNP (classic)	rs110419
ClinGen	rs110419
ebi	rs110419
HLI	rs110419
Exac	rs110419
Gnomad	rs110419
Varsome	rs110419
LitVar	rs110419
Map	rs110419
PheGenI	rs110419
Biobank	rs110419
1000 genomes	rs110419
hgdp	rs110419
ensembl	rs110419
geneview	rs110419
scholar	rs110419
google	rs110419
pharmgkb	rs110419
gwascentral	rs110419
openSNP	rs110419
23andMe	rs110419
SNPshot	rs110419
SNPdbe	rs110419
MSV3d	rs110419
GWAS Ctlg	rs110419

GMAF

0.4054

Max Magnitude

2

rs110419 is a SNP in the LMO1 LIM domain only 1 (rhombotin 1) gene.

A GWAS study of 2,000+ patients (and 6,000+ controls) concluded that the rs110419(A) allele is associated with increased risk for neuroblastoma, with an allelic odds ratio of 1.34 (CI: 1.25 - 1.44, combined p = 5.2 x 10e-16).[PMID 21124317 ]

?

(A;A) (A;G) (G;G)

28

[PMID 18463370 ] Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.

GWAS snp
PMID	[PMID 22941191 ]
Trait	Neuroblastoma
Title	Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
Risk Allele	A
P-val	1E-13
Odds Ratio	1.32 [NR]