| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal
|
| (A;G)
|
1
|
Higher risk of bleeding during coronary angiography?
|
| (G;G)
|
1
|
Higher risk of bleeding during coronary angiography?
|
rs10306114, also known as -842A>G, is a SNP upstream of the cyclooxygenase-1 PTGS1 gene.
A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. None of the eight SNPs tested, including this SNP, were found to be associated with bleeding in the study group, as tested with common confounders controlled.
In the subpopulation of low-risk bleeders with no ongoing clopidogrel treatment and no subsequential PCI operation, this SNP rs10306114 and a co-inherited SNP rs3842787 were statistically associated with bleeding: Again, eight SNPs tested, and for these two with rs10306114(G) and/or rs3842787(T) the increase in bleeding risk is OR=1.94-75.75 (95%) with expected value 12.1, p = 0.012). The confidence interval is wide indicating a small number of positives in the subpopulation, maybe one or two, and the paper had more than sixteen tests with no adjustment of p-values, which makes the test non-definitive (hence small magnitude). [PMID 20691446]
[PMID 19786296] Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
[PMID 17301694
] Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).
[PMID 17495879] Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.
[PMID 19046748] Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
] Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).
