| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
0.5x decreased risk for ovarian cancer
|
| (A;G)
|
1.25
|
0.76x decreased risk for ovarian cancer
|
| (G;G)
|
0
|
|
rs10088218 is a SNP on chromosome 8q24, >700 kb distal to the CMYC gene in an area termed a 'gene desert'.
A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 8 × 10e-15) evidence for slightly reduced risk associated with the rs10088218(A) allele, with an odds ratio of 0.76 (CI: 0.7 – 0.81) as calculated for the serous subtype (of ovarian cancer).[PMID 20852632
]
A large study of over 18,000 patients with epithelial ovarian cancer, including BRCA1 and BRCA2 carriers and a meta-analysis, has also found similar levels of decreased risk for the rs10088218(A) allele.[PMID 25581431]
| GWAS snp
|
| PMID
|
[PMID 20852632]
|
| Trait
|
|
| Title
|
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
|
| Risk Allele
|
G
|
| P-val
|
3E-9
|
| Odds Ratio
|
1.19 [1.12-1.25]
|
[PMID 22235027] Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.
[PMID 22253144] Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.
| GWAS snp
|
| PMID
|
[PMID 23535730]
|
| Trait
|
Ovarian cancer
|
| Title
|
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
| Risk Allele
|
|
| P-val
|
1E-17
|
| Odds Ratio
|
1.29 [1.21-1.36]
|
[PMID 23133607] Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.
[PMID 25173882] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population
]
