|(G;G)||1.9||0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.|
|(G;T)||3||1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.|
|(T;T)||3||1.4x increased risk of Atrial Fibrillation and cardioembolic stroke|
|?||(G;G) (G;T) (T;T)||28|
Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[PMID 17603472]
[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4).
[PMID 19141561] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|Condition||Atrial fibrillation/atrial flutter|
[PMID 21414601] Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting
[PMID 21760908] Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population
[PMID 20031626] Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
[PMID 20170812] Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.
[PMID 20173747] Common variants in KCNN3 are associated with lone atrial fibrillation.
[PMID 20606429] Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
[PMID 20671249] The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.
[PMID 20676228] Lone AF - etiologic factors and genetic insights into pathophysiolgy.
[PMID 22726630] Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.
[PMID 22818067] Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.
[PMID 23178686] Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation.
[PMID 23428961] Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.
[PMID 24065534] Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis
[PMID 25684755] Common Genetic Variants and Response to Atrial Fibrillation Ablation
[PMID 26005361] Association of common variations on chromosome 4q25 and left atrial volume in patients with atrial fibrillation
[PMID 29624624] Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort.