The write-up says that SNP rs34637584 is the "cause" of the disease. However, isn't having the SNP merely associated with a higher incidence of the disease? Is it really the *cause* ?
- agreed, but a single copy is a certainly a very significant factor as stated in [PMID 18539534]
- The risk of PD for a person who inherits the LRRK2 Gly2019Ser mutation was 28% at age 59 years, 51% at 69 years, and 74% at 79 years. The motor symptoms (eg, disease severity, rate of progression, occurrence of falls, and dyskinesia) and non-motor symptoms (eg, cognition and olfaction) of LRRK2-associated PD were more benign than those of idiopathic PD. Mutations in LRRK2 are a clinically relevant cause of PD that merit testing in patients with hereditary PD and in subgroups of patients with PD. However, this knowledge should be applied with caution in the diagnosis and counselling of patients.
- I'd welcome your edits to rs34637584 for a wording you feel better captures the risk vs cause distinction. cariaso 15:54, 30 May 2011 (UTC)