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That is not a reliable source. I have this genotype and I lose weight easily with a completely sedentary lifestyle, just by restricting carbs and calories.

Anecdotal evidence must remain unacceptable. Nevertheless, the summary has been edited for clarity. Taurus (talk) 21:58, 5 July 2014 (UTC)
I was not suggesting that my experience should count as evidence, of course, I was merely pointing out that it would give me reason to doubt the validity of the claim. For comparison, all my known hair texture genes are for wavy/curly hair, but my hair is stick-straight. However, I don't doubt that it's just an individual glitch, because there is peer-reviewed evidence that my genes do tend to correspond to wavy/curly hair. For this geneset here, however, I have not been able to find any acceptable evidence that the claim is true. The new citation on this page only points to a patent application. Any hack trying to come up with a pseudoscientific fad diet system can apply for a patent, and indeed they can obtain the patent for the product even if it's based on complete malarkey, as long as it's novel. Can you provide a peer-reviewed citation that indicated this geneset does what they say it does? Thank you.
I have modified the genoset text to begin to soften the claims. I agree that evidence is lacking, but I'm interested in maintaining some form of the genoset as I think it is one of very few examples of possible epistasis, and it generates a testable hypothesis where behavioral changes are possible. Please continue to edit or comment and help me to reach and agreeable middle ground, where we do not claim too much, but we can keep an eye on this to see if future research supports or refutes the hypothesis. --- cariaso 15:01, 20 July 2014 (UTC)