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TG

From SNPedia
is agene
is mentioned by
Full namethyroglobulin
EntrezGene7038
PheGenI7038
VariationViewer7038
ClinVarTG
GeneCardsTG
dbSNP7038
DiseasesTG
SADR7038
HugeNav7038
wikipediaTG
googleTG
gopubmedTG
EVSTG
HEFalMpTG
MyGene2TG
23andMeTG
UniProtP01266
OMIM188450
# SNPs27
 Max MagnitudeChromosome positionSummary
rs11535853132,971,813
rs1219126460132,923,397
rs1219126470132,906,786
rs1219126480132,882,609
rs1219126490132,967,797
rs1219126500133,022,121
rs1378544330132,898,809
rs1378544340133,029,907
rs169047740132,888,250
rs1802233.5132,888,007
rs1995995910132,941,493
rs20695500132,888,141
rs20695560132,908,273
rs20695610132,963,038
rs20695660133,017,940
rs20767390132,971,804
rs20767402132,971,813
rs22298430132,888,417
rs2294025133,133,268
rs2687836133,050,021
rs2741200133,059,588
rs353014330132,871,398
rs3754242920133,012,017
rs7546589070132,948,928
rs7742747020132,873,226
rs853308132,917,672
rs853326132,897,729

According to the OMIM entry, Thyroglobulin is the glycoprotein precursor to the thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). Dumont et al. (1989) noted that thyroglobulin provides 3 things: a thyroid hormone precursor, storage of iodine, and storage of inactive thyroid hormones.

The gene's polymorphisms have primarily been associated with Thyroid cancer, and with Hashimoto's thyroiditis and Graves' disease subtypes of AITD (Autoimmune thyroid disease or Autoimmune thyroiditis).

[PMID 14657345OA-icon.png] This 2003 article titled "Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease" found that within the TG gene, "exon 10-12 SNP cluster and an exon 33 SNP were significantly associated with AITD."