Sex-hormone binding globulin (SHBG) is produced largely in the liver but also in other organs to a minor extent. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable. Polymorphisms in the SHBG gene, such as Rs1799941 have been associated with levels of circulating steroid hormones. Abnormally low or high levels of SHBG have been linked to a number of conditions, including obesity, type II diabetes and infertility.
SNPs in SHBG:
[PMID 19574343] Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
[PMID 19064566] Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women
[PMID 9435448] Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit