One of 42 more SNPs associated with rheumatoid arthritis
based on a meta-analysis of 30,000 patients, most with odds ratios of 1.01 - 1.2. 10.1038/nature12873
|?|| (A;A) (A;G) (G;G) ||28|
] A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1
[PMID 20427696] Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.
[PMID 20565855] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 21383846] Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
[PMID 22877655] Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC)
[PMID 23285256] Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism