|(A;A)||2||~2x increased risk for Parkinson's disease, and, essential tremor|
|(A;G)||1.5||Slightly increased risk of developing Parkinson's Disease|
|(G;G)||1||Normal risk of developing Parkinson's Disease|
A follow-up case-control study replicated the original association of rs9652490(A;A) to an ~2x increased risk for Parkinson's disease, but also found the same risk for essential tremor (ET), thus linking the two diseases. The ET study was based on ~300 patients.[PMID 19720553]
23andMe blog "In a combined analysis of 752 subjects with essential tremor from Iceland, Austria, Germany and the United States and 15,797 controls, Stefansson et al found that the G version of rs9652490 in the LINGO1 gene is associated with increased odds of the condition. Carrying one G increases the odds of essential tremor by 1.55 times compared to two As. The approximately 5% of the population with European ancestry with two Gs has 2.40 times increased odds."
|Title||Variant in the sequence of the LINGO1 gene confers risk of essential tremor|
|Odds Ratio||1.55 [1.35-1.79]|
[PMID 19908305] Role of LINGO1 polymorphisms in Parkinson's disease
[PMID 20117178] Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis
[PMID 20310002] LINGO1 polymorphisms are associated with essential tremor in Europeans
[PMID 20951767] LINGO1 rs9652490 variant in Parkinson disease patients
[PMID 21264305] LINGO1 Variants in the French-Canadian Population
[PMID 22166413] Genetics of essential tremor
[PMID 22710005] Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson's disease: twelve studies and a meta-analysis
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20369371] LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
[PMID 20372186] Replication of the LINGO1 gene association with essential tremor in a North American population.
[PMID 20600614] Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population.
[PMID 21158743] Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians.
[PMID 21207446] LINGO1 gene analysis in Parkinson's disease phenotypes.
[PMID 21219542] Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
[PMID 21955595] LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease: results of a meta-analysis.
[PMID 22425540] LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23574883] LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis