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rs9561778

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1 Normal risk of adverse drug reactions from cyclophosphamide treatments
(G;T) 1.5 ~2x increased risk of adverse drug reactions from cyclophosphamide treatments
(T;T) 1.5 ~2x increased risk of adverse drug reactions from cyclophosphamide treatments
ReferenceGRCh38 38.1/141
Chromosome13
Position95061461
GeneABCC4
is asnp
is mentioned by
dbSNPrs9561778
dbSNP (classic)rs9561778
ClinGenrs9561778
ebirs9561778
HLIrs9561778
Exacrs9561778
Gnomadrs9561778
Varsomers9561778
LitVarrs9561778
Maprs9561778
PheGenIrs9561778
Biobankrs9561778
1000 genomesrs9561778
hgdprs9561778
ensemblrs9561778
geneviewrs9561778
scholarrs9561778
googlers9561778
pharmgkbrs9561778
gwascentralrs9561778
openSNPrs9561778
23andMers9561778
SNPshotrs9561778
SNPdbers9561778
MSV3drs9561778
GWAS Ctlgrs9561778
GMAF0.1837
Max Magnitude1.5
? (G;G) (G;T) (T;T) 28


rs9561778 is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 gene.

A stepwise case-control study of ~400 breast cancer Japanese patients receiving cyclophosphamide-based combination chemotherapy, roughly divided equally between those having or not having serious adverse drug reactions (ADRs), concluded that carriers of rs9561778(T) allele had a ~2x higher risk of ADRs. The ADRs for these patients tended to be gastrointestinal toxicity and leukopenia/neutropenia.[PMID 19696793]




[PMID 25677905] Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients