Geno
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Mag
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Summary
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(G;G)
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1
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Normal risk of adverse drug reactions from cyclophosphamide treatments
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(G;T)
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1.5
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~2x increased risk of adverse drug reactions from cyclophosphamide treatments
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(T;T)
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1.5
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~2x increased risk of adverse drug reactions from cyclophosphamide treatments
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rs9561778 is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 gene.
A stepwise case-control study of ~400 breast cancer Japanese patients receiving cyclophosphamide-based combination chemotherapy, roughly divided equally between those having or not having serious adverse drug reactions (ADRs), concluded that carriers of rs9561778(T) allele had a ~2x higher risk of ADRs. The ADRs for these patients tended to be gastrointestinal toxicity and leukopenia/neutropenia.[PMID 19696793]
[PMID 25677905] Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients