|?|| (C;C) (C;T) (T;T) ||28|
is a SNP on chromosome 6.
A case control study of ~2,000 women found that each rs9379896(C) allele was associated with an average increase in age at menopause of ~1 month. This also meant that each rs9379896(T) allele yielded an odds ratio of 1.13 (CI: 1.01–1.27, p = 3.8 x 10e-2) of early menopause, defined as occurring before the age of 46.[PMID 20952801]
Overall, women homozygous for the "early" alleles at all 4 SNPs found in this study were ~4 times more likely to undergo menopause early compared to women who had a total of 3 or less risk alleles. However, the ability to predict which women will actually undergo early menopause using these 4 SNPs is still low.[PMID 20952801]