rs9288516

plus

Geno	Mag	Summary
(A;A)	2	2x higher risk for hepatocellular cancer
(A;T)	2	2x higher risk for hepatocellular cancer
(T;T)	0	common in complete genomics

Reference

GRCh38 38.1/141

Chromosome

2

Position

216188541

Gene

XRCC5

is a	snp
is	mentioned by
dbSNP	rs9288516
dbSNP (classic)	rs9288516
ClinGen	rs9288516
ebi	rs9288516
HLI	rs9288516
Exac	rs9288516
Gnomad	rs9288516
Varsome	rs9288516
LitVar	rs9288516
Map	rs9288516
PheGenI	rs9288516
Biobank	rs9288516
1000 genomes	rs9288516
hgdp	rs9288516
ensembl	rs9288516
geneview	rs9288516
scholar	rs9288516
google	rs9288516
pharmgkb	rs9288516
gwascentral	rs9288516
openSNP	rs9288516
23andMe	rs9288516
SNPshot	rs9288516
SNPdbe	rs9288516
MSV3d	rs9288516
GWAS Ctlg	rs9288516

GMAF

0.1809

Max Magnitude

2

?

(A;A) (A;T) (T;T)

28

rs9288516 is a SNP in the XRCC5 gene.

A study of ~700 Chinese patients with hepatocellular carcinoma (HCC) compared to controls indicated an increased risk for rs9288516(A) carriers (odds ratio 2.02, CI: 1.42-2.86, TA+AA versus TT) even after Bonferroni correction (P(corrected) = 0.002). The effect was more significant in HBsAg infected subjects than non-infected subjects.[PMID 21304054] [PMID 17389609] Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.

[PMID 19318434 ] Associations between polymorphisms in DNA repair genes and glioblastoma.

[PMID 27852033 ] The relationship between polymorphisms of XRCC5 genes with astrocytoma prognosis in the Han Chinese population.