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rs9263726

From SNPedia

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Geno Mag Summary
(A;A) 3 In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
(A;G) 3 In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
(G;G) 0 common/normal
ReferenceGRCh38 38.1/141
Chromosome6
Position31138722
GenePSORS1C1, PSORS1C2
is asnp
is mentioned by
dbSNPrs9263726
dbSNP (classic)rs9263726
ClinGenrs9263726
ebirs9263726
HLIrs9263726
Exacrs9263726
Gnomadrs9263726
Varsomers9263726
LitVarrs9263726
Maprs9263726
PheGenIrs9263726
Biobankrs9263726
1000 genomesrs9263726
hgdprs9263726
ensemblrs9263726
geneviewrs9263726
scholarrs9263726
googlers9263726
pharmgkbrs9263726
gwascentralrs9263726
openSNPrs9263726
23andMers9263726
SNPshotrs9263726
SNPdbers9263726
MSV3drs9263726
GWAS Ctlgrs9263726
GMAF0.1139
Max Magnitude3
? (A;A) (A;G) (G;G) 28


The minor allele of this SNP, rs9263726, is reported to 100% predictive of the presence of an HLA-B*58:01 allele, at least in Japanese populations, and therefore also of greatly increased risk for HLA-B*58:01 related susceptibilities. An example of such a susceptibility is the greatly (>50X) increased odds of developing severe side effects from taking allopurinol.[PMID 21912425]


[PMID 21912425] A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients


[PMID 33356553] Genetic susceptibilities and prediction modeling of carbamazepine and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.