rs858518
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Make rs858518(C;C) |
| Make rs858518(C;T) |
| Make rs858518(T;T) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 17 |
| Position | 7629707 |
| Gene | SAT2, SHBG |
| is a | snp |
| is | mentioned by |
| dbSNP | rs858518 |
| dbSNP (classic) | rs858518 |
| ClinGen | rs858518 |
| ebi | rs858518 |
| HLI | rs858518 |
| Exac | rs858518 |
| Gnomad | rs858518 |
| Varsome | rs858518 |
| LitVar | rs858518 |
| Map | rs858518 |
| PheGenI | rs858518 |
| Biobank | rs858518 |
| 1000 genomes | rs858518 |
| hgdp | rs858518 |
| ensembl | rs858518 |
| geneview | rs858518 |
| scholar | rs858518 |
| rs858518 | |
| pharmgkb | rs858518 |
| gwascentral | rs858518 |
| openSNP | rs858518 |
| 23andMe | rs858518 |
| SNPshot | rs858518 |
| SNPdbe | rs858518 |
| MSV3d | rs858518 |
| GWAS Ctlg | rs858518 |
| GMAF | 0.4256 |
| Max Magnitude | 0 |
is a SNP in the sex-hormone binding globulin (SHBG) gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.
[PMID 19064566
] Ten SNPs within or close to the SHBG gene were significantly associated with SHBG levels as was the (TAAAA)(n) polymorphism. The best-fitting combination of rs6259, rs858521, and rs727428 and body mass index, waist, hip, age, and smoking status accounted for 24% of the variance in SHBG levels (natural logarithm transformed).
