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rs838133

From SNPedia

Odds preferring sweet snack
Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1.1 Lower odds of preferring candy or sweet snacks
(C;T) 1.2 Sweeth tooth tendency; slightly higher odds of preferring candy
(T;T) 1.4 Sweet Tooth; Higher odds of preferring candy
ReferenceGRCh38 38.1/141
Chromosome19
Position48756272
GeneFGF21, FUT1
is asnp
is mentioned by
dbSNPrs838133
dbSNP (old)rs838133
ClinGenrs838133
ebirs838133
HLIrs838133
Exacrs838133
Gnomadrs838133
Varsomers838133
Maprs838133
PheGenIrs838133
Biobankrs838133
1000 genomesrs838133
hgdprs838133
ensemblrs838133
gopubmedrs838133
geneviewrs838133
scholarrs838133
googlers838133
pharmgkbrs838133
gwascentralrs838133
openSNPrs838133
23andMers838133
23andMe allrs838133
SNP Nexus

SNPshotrs838133
SNPdbers838133
MSV3drs838133
GWAS Ctlgrs838133
GMAF0.2525
Max Magnitude1.4
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 23372041OA-icon.png]
Trait Dietary macronutrient intake
Title Novel locus including FGF21 is associated with dietary macronutrient intake.
Risk Allele A
P-val 8E-9
Odds Ratio .11 [0.071-0.149] percent decrease
GWAS snp
PMID [PMID 23824729OA-icon.png]
Trait Homocysteine levels
Title Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
Risk Allele A
P-val 7E-9
Odds Ratio .04 [0.028-0.056] unit increase

A 2017 study of ~6,500 individuals with detailed eating records concluded that the rs838133(T) allele (in SNPedia and dbSNP orientation) increased the odds ratio (OR) of being in the top 33% of people for total intake of all types of sweet-tasting foods, with an OR of 1.18 per T-allele (CI: 1.06–1.32, p = 0.003). When sweet intake was divided into “candy” and “cake,” individuals carrying the T-allele had higher candy intake (OR 1.19, CI: 1.07–1.32, p = 0.0007), whereas intake of cake was the same regardless of rs838133 genotype. [PMID 28467924OA-icon.png]

“Genetic associations with traits in 23andMe customers.” 23andMe White Paper.

Salty or sweet - 23andMe blog entry