rs81002874

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;G)	6	BRCA2 variant considered pathogenic for breast cancer
(C;G)	6	BRCA2 variant considered pathogenic for breast cancer
(G;G)	0	common in clinvar
(G;T)	6	BRCA2 variant considered pathogenic for breast cancer

Make rs81002874(T;T)

Reference

GRCh38 38.1/141

Chromosome

13

Position

32363178

Gene

BRCA2

is a	snp
is	mentioned by
dbSNP	rs81002874
dbSNP (classic)	rs81002874
ClinGen	rs81002874
ebi	rs81002874
HLI	rs81002874
Exac	rs81002874
Gnomad	rs81002874
Varsome	rs81002874
LitVar	rs81002874
Map	rs81002874
PheGenI	rs81002874
Biobank	rs81002874
1000 genomes	rs81002874
hgdp	rs81002874
ensembl	rs81002874
geneview	rs81002874
scholar	rs81002874
google	rs81002874
pharmgkb	rs81002874
gwascentral	rs81002874
openSNP	rs81002874
23andMe	rs81002874
SNPshot	rs81002874
SNPdbe	rs81002874
MSV3d	rs81002874
GWAS Ctlg	rs81002874

Max Magnitude

6

rs81002874, known as both c.7977-1G>T and c.7977-1G>C, is a rare mutation in the BRCA2 gene.

Both minor alleles are considered pathogenic for breast cancer in ClinVar.

ClinVar
Risk	rs81002874(A;A) rs81002874(C;C) rs81002874(T;T)
Alt	rs81002874(A;A) rs81002874(C;C) rs81002874(T;T)
Reference	Rs81002874(G;G)
Significance	Pathogenic
Disease	Breast-ovarian cancer Hereditary breast and ovarian cancer syndrome Hereditary cancer-predisposing syndrome not provided
Variation	info
Gene	BRCA2
CLNDBN	Breast-ovarian cancer, familial 2 Hereditary breast and ovarian cancer syndrome Hereditary cancer-predisposing syndrome not provided
Reversed	0
HGVS	NC_000013.10:g.32937315G>A; NC_000013.10:g.32937315G>C; NC_000013.10:g.32937315G>T
CLNSRC	Breast Cancer Information Core (BRCA2)
CLNACC	RCV000258445.1, RCV000031714.6, RCV000045368.5, RCV000162588.2, RCV000486971.1, RCV000113850.1, RCV000197791.1,