|| Normal genotype. slightly higher odds of cannabis dependence
|| uncommon. lowest odds of cannabis dependence
|?|| (A;A) (A;G) (G;G) ||28|
This snp, located in intron 2 of the central cannabinoid receptor CNR1 gene, has been linked to cannabis dependence. [PMID 16917946]
The (G) allele is reported to have a protective effect, and is a defining part of a haplotype that is associated with lower odds of developing cannabis dependence. The (A) allele is more common in all populations studied.
[PMID 19443135] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults
[PMID 18606954] Cannabinoid receptor 1 gene association with nicotine dependence.
[PMID 19016476] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
[PMID 19052543] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
[PMID 19335651] Candidate genes for cannabis use disorders: findings, challenges and directions.
[PMID 21714860] Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (G;G) is also associated with the longest gaze duration for happy faces.
[PMID 28349993] Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome.