||common, but 2.2x higher risk for heart disease
||1.9x risk for heart disease
rs8055236 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.91 (CI 1.33-2.74), and for homozygotes, 2.23 (CI 1.56-3.17). [PMID 17554300]
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.