The (T;T) genotype (as published) of rs8023462
was calculated to represent a hazard ratio of 1.35 (CI: 1.08-1.70) for initiation of tobacco and alcohol use at an earlier age than average. A linked SNP also in the A5A3B4
, showed similiar association. [PMID 18163978
[PMID 18165968] Identification of pharmacogenetic markers in smoking cessation therapy.
[PMID 18571741] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
[PMID 19330903] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
[PMID 19492010] The genetic components of alcohol and nicotine co-addiction: from genes to behavior.
[PMID 23872218] Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors