|(A;A)||0||normal risk for T2D|
|(A;G)||1.9||1.6x risk for T2D|
|(G;G)||2||3.2x risk for T2D|
|?||(A;A) (A;G) (G;G)||28|
rs7923837 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D).
In a study of 500 unrelated Caucasian T2D patients, the rs7923837(G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%.[PMID 18231124]
In a study of ~400 Japanese T2D patients, rs7923837(G) was also associated with type-2 diabetes (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers.[PMID 17971426]
[PMID 18477659] rs7923837 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.13-1.43, p = 1.0 x 10e-4)
[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
[PMID 19117022] rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index in a study of 420 Germans in the MESYBEOP cohort.
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 21059810] Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes
|Title||Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.|
|Odds Ratio||1.1000 [1.08-1.11]|
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