|| 1.20x increased breast cancer risk
|| 1.64x increased breast cancer risk
is a SNP within intron 2 of the FGFR2
gene, as part of a haplotype associated with increased risk for sporadic postmenopausal ER+ breast cancer
in Caucasian patients. The risk shown for this SNP is actually the risk calculated for the tightly associated SNP rs1219648
The distinguishing feature of rs7895676 is experimental evidence indicating that it is one of two SNPs in this intron that appear to have a (the?) functional role associated with the transcriptional regulation of the FGFR2 gene. The minor alleles of both SNPs, rs7895676 and rs2981578, lead to increased transcription and increased breast cancer risk.10.1371/journal.pbio.0060108[PMID 19536173] Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia
[PMID 18462018] Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.
[PMID 19223389] FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
[PMID 19434427] Analytical methods for inferring functional effects of single base pair substitutions in human cancers.
[PMID 19497954] Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.