rs7771980

plus

Geno	Mag	Summary
(C;C)	1	lower bone mineral density in postmenopausal Korean women
(C;T)	1	higher bone mineral density in postmenopausal Spanish women
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

6

Position

45421552

Gene

RUNX2

is a	snp
is	mentioned by
dbSNP	rs7771980
dbSNP (classic)	rs7771980
ClinGen	rs7771980
ebi	rs7771980
HLI	rs7771980
Exac	rs7771980
Gnomad	rs7771980
Varsome	rs7771980
LitVar	rs7771980
Map	rs7771980
PheGenI	rs7771980
Biobank	rs7771980
1000 genomes	rs7771980
hgdp	rs7771980
ensembl	rs7771980
geneview	rs7771980
scholar	rs7771980
google	rs7771980
pharmgkb	rs7771980
gwascentral	rs7771980
openSNP	rs7771980
23andMe	rs7771980
SNPshot	rs7771980
SNPdbe	rs7771980
MSV3d	rs7771980
GWAS Ctlg	rs7771980

GMAF

0.07208

Max Magnitude

1

?

(C;C) (C;T) (T;T)

28

rs7771980, also known as -1025T>C, is a SNP in the RUNX2 gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification.

This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus osteoporosis in several studies, but with different correlations.

In a study of 821 Spanish postmenopausal women, rs7771980(C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype.[PMID 17878995]

In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.[PMID 19424741]

[PMID 18357615 ] Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.