||Cystic fibrosis allele (carrier)
||common in clinvar
rs77010898, also known as Trp1282X, W1282X, W1282* and 3846G>A, is a SNP in the CFTR gene considered pathogenic for cystic fibrosis.
The W1282X mutation is reported to be the most common cystic fibrosis mutation in Ashkenazi Jews, representing 50% of more all CFTR mutations reported (in that population).[PMID 10464623]
An article about a nonprofit, Emily's Entourage, focusing on developing treatments for patients with CFTR nonsense mutations such as W1282X, is available here.
In 23andMe, rs77010898 may be referred to by at least 3 other names: i4000309, i5012037, and i6056299.
FTDNA & MyHeritage name: VG07S29451