| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal
|
| (C;T)
|
2
|
1.45x increased osteoarthritis risk
|
| (T;T)
|
2
|
1.45x increased osteoarthritis risk
|
rs7639618 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.45 (CI: 1.27-1.65, p = 2.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). [PMID 18622395]
[PMID 19054821] Our results suggest that the effect that DVWA amino acid changes have on tubulin binding is unlikely to influence risk of OA in Caucasians.
[PMID 19181678] rs7639618 with knee osteoarthritis with an odds ratio (OR) of 1.29, 95% confidence interval (CI) of 1.15 -1.45 and P of 2.70x10(-5), but not for Europeans
| OMIM | 612401 |
| Desc | OSTEOARTHRITIS SUSCEPTIBILITY 6; OS6 |
| Variant | |
| Related | also |
[PMID 19486942] The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene
[PMID 20238217] Lack of evidence for association between DVWA gene polymorphisms and developmental dysplasia of the hip in Chinese Han population
[PMID 22083612] Association study of the candidate gene for knee osteoarthritis in Koreans.
[PMID 26550167
] The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis
[PMID 26886631] Single Nucleotide Polymorphisms and Osteoarthritis: An Overview and a Meta-Analysis.
] The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis
