[PMID 27556446] TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis.. (2016 article) "An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto’s thyroiditis (HT) (p = 0.018)." (Abstract). ... "Further analysis found that the frequencies of TT genotype in rs7514229 and GG genotype in rs3850641 were lower in the AITDs group than the control group (Table 3), which suggested that people with these genotypes are less susceptible to AITDs (p = 0.016, OR = 0.236, 95% CI = 0.066–0.850 and p = 0.027, OR = 0.492, 95% CI = 0.259–0.935, respectively)."
|(G;G)||1.2||associated with early-onset autoimmune thyroid disease|
|(T;T)||1.5||Less susceptible to autoimmune thyroid diseases|