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rs7514229

From SNPedia

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Geno Mag Summary
(G;G) 1.2 associated with early-onset autoimmune thyroid disease
(T;T) 1.5 Less susceptible to autoimmune thyroid diseases
Make rs7514229(G;T)
ReferenceGRCh38.p2 38.2/147
Chromosome1
Position173185165
GeneTNFSF4
is asnp
is mentioned by
dbSNPrs7514229
dbSNP (old)rs7514229
ClinGenrs7514229
ebirs7514229
HLIrs7514229
Exacrs7514229
Varsomers7514229
Maprs7514229
PheGenIrs7514229
Biobankrs7514229
1000 genomesrs7514229
hgdprs7514229
ensemblrs7514229
gopubmedrs7514229
geneviewrs7514229
scholarrs7514229
googlers7514229
pharmgkbrs7514229
gwascentralrs7514229
openSNPrs7514229
23andMers7514229
23andMe allrs7514229
SNP Nexus

SNPshotrs7514229
SNPdbers7514229
MSV3drs7514229
GWAS Ctlgrs7514229
Max Magnitude1.5
? (G;G) (G;T) (T;T) 28
[PMID 27556446OA-icon.png] TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis.. (2016 article) "An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto’s thyroiditis (HT) (p = 0.018)." (Abstract). ... "Further analysis found that the frequencies of TT genotype in rs7514229 and GG genotype in rs3850641 were lower in the AITDs group than the control group (Table 3), which suggested that people with these genotypes are less susceptible to AITDs (p = 0.016, OR = 0.236, 95% CI = 0.066–0.850 and p = 0.027, OR = 0.492, 95% CI = 0.259–0.935, respectively)."