rs744154
| Orientation | minus |
| Stabilized | minus |
| Make rs744154(C;C) |
| Make rs744154(C;G) |
| Make rs744154(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 13921224 |
| Gene | ERCC4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs744154 |
| dbSNP (classic) | rs744154 |
| ClinGen | rs744154 |
| ebi | rs744154 |
| HLI | rs744154 |
| Exac | rs744154 |
| Gnomad | rs744154 |
| Varsome | rs744154 |
| LitVar | rs744154 |
| Map | rs744154 |
| PheGenI | rs744154 |
| Biobank | rs744154 |
| 1000 genomes | rs744154 |
| hgdp | rs744154 |
| ensembl | rs744154 |
| geneview | rs744154 |
| scholar | rs744154 |
| rs744154 | |
| pharmgkb | rs744154 |
| gwascentral | rs744154 |
| openSNP | rs744154 |
| 23andMe | rs744154 |
| SNPshot | rs744154 |
| SNPdbe | rs744154 |
| MSV3d | rs744154 |
| GWAS Ctlg | rs744154 |
| GMAF | 0.214 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
Previous studies had suggested that the minor allele of this SNP might influence breast cancer. However, a 2009 European study of 30,000 breast cancer cases, compared to 30,000 controls, found no association, or as they put it, "persuasive evidence against an overall association between invasive breast cancer risk and (this SNP)".[PMID 19423537
]
[PMID 19920816] Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
[PMID 22573488] EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
[PMID 22768293] Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
[PMID 17018596] ERCC4 associated with breast cancer risk: a two-stage case-control study using high-throughput genotyping.
[PMID 17945097] [Influences of excision repair cross complementation group 4 genetic variations on DNA damage in lymphocytes among coke oven workers].
[PMID 20062074] A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer.
[PMID 23537993] Tagging SNPs in the ERCC4 gene are associated with gastric cancer risk
[PMID 23720401] Single Nucleotide Polymorphisms in Nucleotide Excision Repair Genes, Cigarette Smoking, and the Risk of Head and Neck Cancer
