||no positive effect of AChE inhibitors for Alzheimer's patients
||some positive effect of AChE inhibitors for Alzheimer's patients
||largest positive effect of AChE inhibitors for Alzheimer's patients
|?|| (C;C) (C;T) (T;T) ||28|
rs733722, also known as -5293C>T, is a SNP near the choline acetyltransferase CHAT gene.
A study of 121 Alzheimer's disease patients treated primarily with the acetylcholinesterase (AChE) inhibitors donepezil or galantamine found different rates of mental decline depending on rs733722 genotypes. Individuals of rs733722(C;C) genotype effectively showed declines in cognition over time equivalent to untreated patients, whereas rs733722(C;T) individuals showed less decline, and rs733722(T;T) patients had a negligible decline over the course of the study (~15 months).[PMID 16424819]
An earlier study by these authors found no association between SNPs in this gene and actual risk for Alzheimer's.[PMID 12759818]
[PMID 18072279] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.
[PMID 18165968] Identification of pharmacogenetic markers in smoking cessation therapy.