||very slight descrease in cortical thickness and IQ; see full description
||very slight decrease in cortical thickness and IQ; see full text
|?|| (A;A) (A;G) (G;G) ||28|
rs7171755 is a SNP near the synaptic cell adhesion glycoprotein-encoding NPTN gene.
A study of ~1,500 adolescents determined that the rs7171755(A) allele is associated with a slightly thinner left hemisphere cortex and also a slight decrease in verbal and nonverbal intelligence (IQ). The differences were really quite slight; each copy of the risk allele decreased cortical thickness by 0.7%, and decreased verbal and nonverbal IQ by 1.8 and 1.4 points, respectively. This study awaits independent replication. Also, note that eight SNPs in the NPTN locus were reported as jointly showing significant association with cortical thickness in addition to rs7171755: rs7176637, rs11854138, rs8028749, rs12185108, rs1564492, rs899981, rs7178269 and rs4075802.10.1038/mp.2013.197