|| 1.3x increased risk of death if diagnosed with breast cancer
|| >1.3x increased risk of death if diagnosed with breast cancer
|?|| (C;C) (C;T) (T;T) ||28|
Two SNPs associated with the antioxidant GPX4 gene, rs713041 and rs757229, are both somewhat correlated (r2=0.61) and are associated with all-cause mortality in breast cancer.
The rs713041(T) allele is associated with an increased risk of death following breast cancer diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).[PMID 17634480]
[PMID 20378690] Genetic variants in selenoprotein genes increase risk of colorectal cancer
[PMID 21733339] SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
[PMID 20003265] Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.
[PMID 20852007] Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.
[PMID 21459128] A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells.
[PMID 22139612] Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.
[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
[PMID 26081749] Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians
[PMID 26446998] Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1