|(C;T)||less likely to gain weight if taking risperidone|
|(T;T)||less likely to gain weight if taking risperidone|
[PMID 17199131] In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs705381(C) allele were less likely to gain significant weight compared to rs705381(T;T) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs8179183 and rs6837793, were also significantly associated with weight profiles in these patients.
[PMID 15060281)] In a study of 461 participants in the HERITAGE cohort (172 African-American, 289 Caucasian), the combination of rs705381 with "PON-126" (RS ID unknown) were found to significantly contribute to trait-anxiety scores. The authors also cite another paper, [PMID 12525679], which found that this SNP accounts for 2.4% of the variation in PON1 expression. Which allele correlates with increased trait-anxiety scores and/or reduced PON1 expression is unclear.
HapMap frequencies for this SNP seem dubious. They list rs705381(T;T) as being at or near 100% for the population groups reported by SNPedia. However, the raw data at HapMap for this SNP are largely no-call (e.g. CEU: NN=87, TT=82, CT=3). The other diversity studies listed at dbSNP show C as the more common allele (e.g. AFD_AFR_PANEL: CC=47.8%, CT=39.1%, TT=13.0%). Anecdotal data submitted by participants at 23andme also show C as being more common (CC=4, CT=1, TT=2). The diversity data have therefore been removed until these discrepancies can be resolved.
[PMID 18618303] A common haplotype within the PON1 promoter region is associated with sporadic ALS.
[PMID 19321847] A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
[PMID 21223581] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
[PMID 23356507] Association between paraoxonase gene and stroke in the Han Chinese population
[PMID 24448003] Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults
[PMID 22884547] Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.
[PMID 22956172] Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD).