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rs689465

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.5x increased risk for mild asthma
(A;G) 1.35x increased risk for asthma
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome1
Position186681714
GenePACERR, PTGS2
is asnp
is mentioned by
dbSNPrs689465
dbSNP (old)rs689465
ClinGenrs689465
ebirs689465
HLIrs689465
Exacrs689465
Varsomers689465
Maprs689465
PheGenIrs689465
Biobankrs689465
1000 genomesrs689465
hgdprs689465
ensemblrs689465
gopubmedrs689465
geneviewrs689465
scholarrs689465
googlers689465
pharmgkbrs689465
gwascentralrs689465
openSNPrs689465
23andMers689465
23andMe allrs689465
SNP Nexus

SNPshotrs689465
SNPdbers689465
MSV3drs689465
GWAS Ctlgrs689465
GMAF0.1171
Max Magnitude
rs689465 is a SNP in the PTGS2 gene, also known as COX-2, that has been associated with increased risk for mild asthma based on a study of 663 Australian patients. The odds ratio for mild asthma associated with (A;A) genotypes was 1.5 (CI: 1.12-2.02, p=0.02).[PMID 18489027]
Neighborrs20417
Distance525
Neighborrs20415
Distance159
[PMID 18085997] Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

[PMID 21304218] Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

[PMID 21538574] Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

[PMID 21848701] Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.

[PMID 22037828] Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.


[PMID 24789723] Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients