| Geno
|
Mag
|
Summary
|
| (C;C)
|
2
|
d3/d3GHR homozygote; possibly longer longevity, at least in males
|
| (T;T)
|
0
|
common/normal
|
rs6873545 is one of several SNPs in the GHR gene that correlates with the presence or absence of exon 3 and thus the (germline) allele known as the d3-GHR allele. The rs6873545(T) allele correlates with the more common allele containing exon 3; rs6873545(C) correlates with the less common d3-GHR allele lacking exon 3.[PMID 17220348
]
[PMID 23812803] The exon 3 polymorphism of the growth hormone receptor is a severity-related factor for osteoporosis
[PMID 24114431] SNPs within the GH signaling pathway are associated with the early IGF-I response to GH replacement therapy in GHD adults
[PMID 20219401] Rapid and high throughput genotyping of the growth hormone receptor exon 3 deleted/full-length polymorphism using a tagSNP.
[PMID 20445798] Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
[PMID 25742716] The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children
]
