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rs66698963

From SNPedia

[PMID 27188529OA-icon.png] Basal plasma phospholipid arachidonic acid (ARA) status was 8% greater in rs66698963 I/I compared with D/D individuals, consistent with previous in vitro data suggesting that the insertion allele enhances n-6 long-chain PUFA synthesis and may confer an adaptive advantage in South Asians (and other populations having a primarily vegetarian diet).

http://www.eurekalert.org/pub_releases/2016-03/mbae-aww032416.php and http://mbe.oxfordjournals.org/content/early/2016/03/09/molbev.msw049.abstract if they stray from a balanced omega-6 to omega-3 diet -- may make people more susceptible to inflammation, and by association, increased risk of heart disease and colon cancer.

ClinVar
Risk rs66698963(-;-) Rs66698963(CTCCCTGCCTCCCCAGGGACTT;CTCCCTGCCTCCCCAGGGACTT)
Alt rs66698963(-;-) Rs66698963(CTCCCTGCCTCCCCAGGGACTT;CTCCCTGCCTCCCCAGGGACTT)
Reference rs66698963(ACTTCTCCCTGCCTCCCCAGGG;ACTTCTCCCTGCCTCCCCAGGG)
Significance Untested
Disease not provided
Variation info
Gene FADS2
CLNDBN not provided
Reversed 0
HGVS NC_000011.9:g.61602537_61602558del22
CLNSRC
CLNACC RCV000149463.1,