|(A;A)||1.5||1.18x increased risk for late-onset Alzheimer’s|
|(A;G)||1.5||1.18x increased risk for late-onset Alzheimer’s|
A 2015 analysis 24 studies totaling 30,000 late-onset Alzheimer's disease patients reported a slight but statistically robust association with the rs6656401(A) minor allele; the odds ratio was 1.18 (CI: 1.15-1.22, p = 1.82e-26).[PMID 24878768]
[PMID 19734903] Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
[PMID 20558149] Complement receptor 1 polymorphisms and risk of late onset Alzheimer's disease
[PMID 21912625] An exploratory study on CLU, CR1 and PICALM and Parkinson disease
[PMID 22216291] Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels
[PMID 22262751] Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.
[PMID 20739100] Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.
[PMID 21347408] Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
[PMID 21358043] PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.
[PMID 21391232] CR1 is associated with amyloid plaque burden and age-related cognitive decline.
[PMID 21726919] CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
[PMID 22015308] Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.
[PMID 22244847] Alzheimer's disease risk factor complement receptor 1 is associated with depression.
[PMID 22343410] A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline.
[PMID 22960360] Association of the CR1 polymorphism with late-onset Alzheimer's disease in Chinese Han populations: A meta-analysis
[PMID 23650005] Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population
|Trait||Alzheimer's disease (late onset)|
|Title||Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.|
|Odds Ratio||1.18 [1.14-1.22]|
[PMID 24878768] An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease
[PMID 26680604] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
[PMID 28567584] rs3851179 Polymorphism at 5' to the PICALM Gene is Associated with Alzheimer and Parkinson Diseases in Brazilian Population.