| Geno
|
Mag
|
Summary
|
| (G;G)
|
1
|
Normal risk of developing lung cancer
|
| (G;T)
|
2
|
Significantly increased risk of developing lung cancer
|
| (T;T)
|
2.5
|
3x increased risk of developing lung cancer
|
rs663048 associated with lung cancer
The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81-7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04-1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke.007;67(17):8406-11]. [PMID 17804757]
