|Trait||Body mass index|
|Title||Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|
|Odds Ratio||0.26 [0.19-0.34] kg/m2 increase|
[PMID 19851340] Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
[PMID 20386550] Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA
[PMID 20380707] The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
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[PMID 19164386] Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
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[PMID 19553259] Common body mass index-associated variants confer risk of extreme obesity.
[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20520848] Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
[PMID 20628085] First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 20725061] MC4R variant is associated with BMI but not response to resistance training in young females.
[PMID 20824172] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
[PMID 21593506] Maternal and offspring adiposity-related genetic variants and gestational weight gain.
[PMID 21952719] Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.
[PMID 22179955] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
[PMID 22466342] beta2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.
|qualified_impact||Insufficiently evaluated pathogenic|
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[PMID 23775818] Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study.
[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length
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[PMID 27829468] Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children.