|(A;A)||2.1||0.43x decreased risk for esophageal cancer|
|(A;C)||2||0.58x decreased risk for esophageal cancer|
|Gene||MIR3184, MIR423, NSRP1|
A study of 346 Caucasians with esophageal cancer found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as rs6505162, and the overall risk of esophageal cancer increased with increasing numbers of unfavorable SNPs.10.1158/1940-6207.CAPR-08-0135 [PMID 19138993]
|snp near microRNA|
discussed in nature
[PMID 19950226] SNPs in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high risk women
[PMID 22028396] Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer
[PMID 22593246] A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk
[PMID 18521189] Genetic variants of miRNA sequences and non-small cell lung cancer survival.
[PMID 19047128] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
[PMID 19458495] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
[PMID 22818121] The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer
[PMID 24205249] MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma
[PMID 24413317] MicroRNA sequence polymorphisms and the risk of different types of cancer
[PMID 24854593] Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population
[PMID 25663458] Genetic analysis and preliminary function study of miR-423 in breast cancer
[PMID 25901206] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease
[PMID 25926693] The polymorphism of rs6505162 in miR-423 coding region and recurrent pregnancy loss
[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population
[PMID 27421647] Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population.