||higher risk for Achilles tendinopathy?
rs650108 is a SNP in the matrix metallopeptidase 3 MMP3 gene on ch 11.
[PMID 19042922] A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs650108, the (A;A) genotype had an odds ratio of 4.9 (CI: 1.0 to 24.1, p = 0.043).
[PMID 19762026] Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: Case-control study and a meta-analysis
[PMID 21134112] Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis
[PMID 19318431] No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
[PMID 19435861] No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.
[PMID 22671570] MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
[PMID 26191285] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair