|(C;T)||2||2.3x risk of rheumatoid arthritis|
|(T;T)||2.1||5.2x risk of rheumatoid arthritis|
|?||(C;C) (C;T) (T;T)||28|
rs6457617 has been reported in a large study to be associated with rheumatoid arthritis. This SNP is reported to be the most statistically significant of many SNPs similarly located in the MHC region.
Tag-snp for HLA-DQA1*03.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 2.36 (CI 1.97-2.84), and for homozygotes, 5.21 (CI 4.31-6.30). [PMID 17554300]
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|Odds Ratio||NR NR|
[PMID 19714643] TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
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|Odds Ratio||1.37 [1.28-1.47]|
[PMID 21750679] Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis
|Title||A genome-wide association study identifies two new risk loci for Graves' disease.|
|Odds Ratio||1.4000 [1.32-1.48]|
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