|Alzheimer's related, 1% geno is good|
|| resistance to Alzheimer's disease
|| carrier for reduced risk of Alzheimer's disease
rs63750847, also known as c.2017G>A, p.Ala673Thr and A673T, represents an infrequent variant in the APP gene on chromosome 21. The minor allele has been reported to reduce risk for Alzheimer's disease.[PMID 22801501]
source Detected in 1 patient with 2 ischemic strokes and myocardial infarction. No family history; no amyloid deposition.
The variant also makes developing Alzheimer's disease four times less likely across all age groups. "It confers extraordinarily strong protection," said Stefansson. source
[PMID 23510020] Have we learnt all we need to know from genetic studies - is genetics over in Alzheimer's disease?